The Lipid Library

Literature Survey - Matrix-Assisted Laser Desorption Mass Spectrometry of Lipids

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI) usually but not exclusively linked to time-of-flight (TOF) instruments is proving increasingly useful for the analysis of lipids, including triacylglycerols, phospholipids and glycolipids.

The following references were collected as part of our regular literature reviews for our own research purposes. We cannot claim to have covered the subject exhaustively, but we have done our best.  References are listed alphabetically by the first author of a paper, but not necessarily chronologically by that author. New references may be added at irregular intervals - check the bottom of the page for when it was last updated.

• Adibhatla,R.M., Hatcher,J.F. and Dempsey,R.J. Lipids and lipidomics in brain injury and diseases. AAPS J., 8, E314-E321 (2006).
• Al-Saad,K.A., Siems,W.F., Hill,H.H., Zabrouskov,V. and Knowles,N.R. Structural analysis of phosphatidylcholines by post-source decay matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Am. Soc. Mass Spectrom., 14, 373-382 (2003).
• Al-Saad,K.A., Zabrouskov,V., Siems,W.F., Knowles,N.R., Hannan,R.M. and Hill,H.H. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of lipids: ionization and prompt fragmentation patterns. Rapid Commun. Mass Spectrom., 17, 87-96 (2003).
• Aoki,K., Sugiyama,S., Dulaney,J.T. Itonori,S. and Sugita,M. Classification into a novel mollu-series of neutral glycosphingolipids from the lamp shell, Lingula unguis. J. Oleo Sci., 51, 463-472 (2002).
• Aoki,K., Uchiyama,R., Itonori,S., Sugita,M., Che,F.S., Isogai,A., Hada,N., Hada,J., Takeda,T., Kumagai,H. and Yamamoto,K. Structural elucidation of novel phosphocholine-containing glycosylinositol-phosphoceramides in filamentous fungi and their induction of cell death of cultured rice cells. Biochem. J., 378, 461-472 (2004).
• Aoki,K., Uchiyama,R., Yamauchi,S., Katayama,T., Itonori,S., Sugita,M., Hada,N., Yamada-Hada,J., Takeda,T., Kumagai,H. and Yamamoto,K. Newly discovered neutral glycosphingolipids in Aureobasidin A-resistant Zygomycetes - Identification of a novel family of gala-series glycolipids with core Gal alpha 1-6Gal beta 1-6Gal beta sequences. J. Biol. Chem., 279, 32028-32034 (2004).
• Arnhold,J., Osipov,A.N., Spalteholz,H., Panasenko,O.M. and Schiller,J. Formation of lysophospholipids from unsaturated phosphatidylcholines under the influence of hypochlorous acid. Biochim. Biophys. Acta, 1572, 91-100 (2002).
• Asbury,G.R., Al Saad,K., Siems,WF, Hannan,R.M.. and Hill,H.H. Analysis of triacylglycerols and whole oils by matrix-assisted laser desorption/ionization time of flight mass spectrometry. J. Am. Soc. Mass Spectrom., 10, 983-991 (1999).
• Ayorinde,F.O. Determination of the molecular distribution of triacylglycerol oils using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Lipid Technology, 12, 41-44 (2000).
• Ayorinde,F.O., Elhilo,E. and Hlongwane,C. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of canola, castor and olive oils. Rapid Commun. Mass Spectrom., 13, 737-739 (1999).
• Ayorinde,F.O., Elhilo,E., Hlongwane,C. and Saeed,K.A. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of Vernonia galamensis oil. J. Am. Oil Chem. Soc., 76, 1217-1221 (1999).
• Ayorinde,F.O., Eribo,B.E., Balan,K.V., Johnson,J.H. and Wan,L.W. Determination of major triacylglycerol components of polyunsaturated specialty oils using matrix-assisted laser desorption ionization time-of-fight mass spectrometry. Rapid Commun. Mass Spectrom., 13, 937-942 (1999).
• Ayorinde,F.O., Garvin,K. and Saeed,K. Determination of the fatty acid composition of saponified vegetable oils using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 14, 608-615 (2000).
• Ayorinde,F.O., Keith,Q.L. and Wan,L.W. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of cod liver oil and the effect of analyte/matrix concentration on signal intensities. Rapid Commun. Mass Spectrom., 13, 1762-1769 (1999).
• Balazy,M. Eicosanomics: targeted lipidomics of eicosanoids in biological systems. Prostaglandins Other Lipid Mediators, 73, 173-180 (2004).
• Batrakov,S.G., Konova,.IV., Sheichenko,V.I., Esipov,S.E., Galanina,L.A. and Istratova,L.N. Unusual fatty acid composition of cerebrosides from the filamentous soil fungus Mortierella alpina. Chem. Phys. Lipids, 117, 45-51 (2002).
• Batrakov,S.G., Pivovarova,T.A., Esipov,S.E., Sheichenko,V.I. and Karavaiko,G.I. beta-D-Glucopyranosyl caldarchaetidylglycerol is the main lipid of the acidophilic, mesophilic, ferrous iron-oxidising archaeon Ferroplasma acidiphilum. Biochim. Biophys. Acta, 1581, 29-35 (2002).
• Bayir,H., Tyurin,V.A., Tyurina,YY., Viner,R., Ritov,V., Amoscato,A.A., Zhao,Q., Zhang,X.J., Janesko-Feldman,K.L., Alexander,H., Basova,L.V., Clark,R.S.B., Kochanek,P.M. and Kagan,V.E. Selective early cardiolipin peroxidation after traumatic brain injury: An oxidative lipidomics analysis. Ann. Neurol., 62, 154-169 (2007).
• Benard,S., Arnhold,J., Lehnert,M., Schiller,J. and Arnold,K. Experiments towards quantification of saturated and polyunsaturated diacylglycerols by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry. Chem. Phys. Lipids, 100, 115-125 (1999).
• Ben-Menachem,G., Kubler-Kielb,J., Coxon,B. Yergey,A. and Schneerson,R. A newly discovered cholesteryl galactoside from Borrelia burgdorferi. Proc. Natl. Acad. Sci. USA, 100, 7913-7918 (2003).
• Bizzozero,O.A., Malkoski,S.P., Mobarak,C., Bixler,H.A. and Evans,J.E. Mass-spectrometric analysis of myelin proteolipids reveals new features of this family of palmitoylated membrane proteins. J. Neurochem., 81, 636-645 (2002).
• Borner,K., Malmberg,P., Mansson,J.E. and Nygren,H. Molecular imaging of lipids in cells and tissues. Int. J. Mass Spectrom., 260, 128-136 (2007).
• Boumann,H.A., Hopmans,E.C., van de Leemput,I., Op den Camp,H.J.M., van de Vossenberg,J., Strous,M., Jetten,M.S.M., Damste,J.S.S. and Schouten,S. Ladderane phospholipids in anammox bacteria comprise phosphocholine and phosphoethanolamine headgroups. FEMS Microbiol. Letts, 258, 297-304 (2006).
• Briand,G., Fontaine,M., Schubert,R., Ricart,G., Degand,P. and Vamecq,J. Direct analysis by electrospray ionization and matrix-assisted laser desorption ionization MS of standard and urinary acylcarnitines. Comparison with fast atom bombardment and GC CI MS. J. Mass Spectrom., 30, 1731-1741 (1995).
• Budimir,N., Blais,J.C., Fournier,F. and Tabet,J.C. The use of desorption/ionization on porous silicon mass spectrometry for the detection of negative ions for fatty acids. Rapid Commun. Mass Spectrom., 20, 680-684 (2006).
• Calvano,C.D., Aresta,A., Palmisano,F. and Zambonin,C.G. A laser desorption ionization time-of-flight mass spectrometry investigation into triacylglycerols oxidation during thermal stressing of edible oils. Anal. Bioanal. Chem., 389, 2075-2084 (2007).
• Casabuono,A.C., D'Antuono,A., Sato,Y., Nonami,H., Ugalde,R., Lepek,V., Erra-Balsells,R. and Couto,A.S. A matrix-assisted laser desorption/ionization mass spectrometry approach to the lipid A from Mesorhizobium loti. Rapid Commun. Mass Spectrom., 20, 2175-2182 (2006).
• Cha,S.W. and Yeung,E.S. Colloidal graphite-assisted laser desorption/ionization mass spectrometry and MSn of small molecules. 1. Imaging of cerebrosides directly from rat brain tissue. Anal. Chem., 79, 2373-2385 (2007).
• Chernushevich,I.V., Loboda, A.V. and Thomson,B.A. An introduction to quadrupole/time-of-flight mass spectrometry J. Mass Spectrom., 36, 849-865 (2001).
• Choma,A. and Komaniecka,I. The polar lipid composition of Mesorhizobium ciceri. Biochim. Biophys. Acta, 1631, 188-196 (2003).
• Darsow,K,H., Lange,H.A., Resch,M., Walter,C. and Buchholz,R. Analysis of a chlorosulfolipid from Ochromonas danica by matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 21, 2188-2194 (2007).
• Dinadayala,P., Laval,F., Raynaud,C., Lemassu,A., Laneelle,M.A., Laneelle,G. and Daffe,M. Tracking the putative biosynthetic precursors of oxygenated mycolates of Mycobacterium tuberculosis - Structural analysis of fatty acids of a mutant strain devoid of methoxy- and ketomycolates. J. Biol. Chem., 278, 7310-7319 (2003).
• Dreisewerd,K., Muthing,J., Rohlfing,A., Meisen,I., Vukelic,Z., Peter-Katalinic,J., Hillenkamp,F. and Berkenkamp,S. Analysis of gangliosides directly from thin-layer chromatography plates by infrared matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry with a glycerol matrix. Anal. Chem., 77, 4098-4107 (2005).
• Dreisewerd,K., Lemaire,R., Pohlentz,G., Salzet,M., Wisztorski,M., Berkenkamp,S. and Fournier,I. Molecular profiling of native and matrix-coated tissue slices from rat brain by infrared and ultraviolet laser desorption/ionization orthogonal time-of-flight mass spectrometry. Anal. Chem., 79, 2463-2471 (2007).
• Ejsing,C.S., Moehring,T., Bahr,U., Duchoslav,E., Karas,M., Simons,K. and Shevchenko,A. Collision-induced dissociation pathways of yeast sphingolipids and their molecular profiling in total lipid extracts: a study by quadrupole TOF and linear ion trap-orbitrap mass spectrometry. J. Mass Spectrom., 41, 372-389 (2006).
• Ekroos,K, Chernushevich,IV, Simons,K and Shevchenko,A. Quantitative profiling of phospholipids by multiple precursor ion scanning on a hybrid quadrupole time-of-flight mass spectrometer. Anal. Chem., 74, 941-949 (2002).
• Ekroos,K., Ejsing,C.S., Bahr,U., Karas,M., Simons,K. and Shevchenko,A. Charting molecular composition of phosphatidylcholines by fatty acid scanning and ion trap MS3 fragmentation. J. Lipid Res., 44, 2181-2192 (2003).
• Estrada,R., Borchman,D., Reddan,J., Hitt,A. and Yappert,M.C. In vitro and in situ tracking of choline-phospholipid biogenesis by MALDI TOF-MS. Anal. Chem., 78, 1174-1180 (2006).
• Estrada,R. and Yappert,M.C. Alternative approaches for the detection of various phospholipid classes by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Mass Spectrom., 39, 412-422 (2004).
• Estrada,R. and Yappert,M.C. Regional phospholipid analysis of porcine lens membranes by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Mass Spectrom., 39, 1531-1540 (2004).
• Fuchs,B., Schiller,E., Wagner,U., Hantzschel,H. and Arnold,K. The phosphatidylcholine/lysophosphatidylcholine ratio in human plasma is an indicator of the severity of rheumatoid arthritis: Investigations by P-31 NMR and MALDI-TOF MS. Clin. Biochem., 38, 925-933 (2005).
• Fuchs,B., Mueller,K., Goeritz,F., Blottner,S. and Schiller,J. Characteristic oxidation products of choline plasmalogens are detectable in cattle and roe deer spermatozoa by MALDI-TOF mass spectrometry. Lipids, 42, 991-998 (2007).
• Fuchs,B., Schiller,J. and Cross,M.A. Apoptosis-associated changes in the glycerophospholipid composition of hematopoietic progenitor cells monitored by P-31 NMR spectroscopy and MALDI-TOF mass spectrometry. Chem. Phys. Lipids, 150, 229-238 (2007).
• Fuchs,B., Schiller,J., Suess,R., Schuerenberg,M. and Suckau,D. A direct and simple method of coupling matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) to thin-layer chromatography (TLC) for the analysis of phospholipids from egg yolk. Anal. Bioanal. Chem., 389, 827-834 (2007).
• Fuchs,B., Schober,C., Richter,G., Suess,R. and Schiller,J. MALDI-TOF MS of phosphatidylethanolamines: Different adducts cause different post source decay (PSD) fragment ion spectra. J. Biochem. Biophys. Methods, 70, 689-692 (2007).
• Fujiwaki,T., Tasaka,M., Takahashi,N., Kobayashi,H., Murakami,Y., Shimada,T. and Yamaguchi,S. Quantitative evaluation of sphingolipids using delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard - Practical application to cardiac valves from a patient with Fabry disease. J. Chromatogr. B, 832, 97-102 (2006).
• Fujita,Y., Naka,T., Doi,T. and Yano,I. Direct molecular mass determination of trehalose monomycolate from 11 species of mycobacteria by MALDI-TOF mass spectrometry. Microbiology, 151, 1443-1452 (2005).
• Fujita,Y., Naka,T., McNeil,M.R. and Yano,I. Intact molecular characterization of cord factor (trehalose 6,6'-dimycolate) from nine species of mycobacteria by MALDI-TOF mass spectrometry. Microbiology, 151, 3403-3416 (2005).
• Fujiwaki,T., Yamaguchi,S., Sukegawa,K. and Taketomi,T. Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in tissues from sphingolipidosis patients. J. Chromatogr. B, 731, 45-52 (1999).
• Fujiwaki,T., Yamaguchi,S., Sukegawa,K. and Taketomi,T. Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in cultured skin fibroblasts from sphingolipidosis patients. Brain Develop., 24, 170-173 (2002).
• Fujiwaki,T., Yamaguchi,S., Tasaka,M., Sakura,N. and Taketomi,T. Application of delayed extraction-matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in pericardial fluid, peritoneal fluid and serum from Gaucher disease patients. J. Chromatogr. B, 776, 115-123 (2002).
• Fujiwaki,T., Yamaguchi,S., Tasaka,M., Takayanagi,M., Isobe,M. and Taketomi,T. Evaluation of sphingolipids in vitreous bodies from a patient with Gaucher disease, using delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry. J. Chromatogr. B, 806, 47-51 (2004).
• Garrett,T.J., Prieto-Conaway,M.C., Kovtoun,V., Bui,H., Izgarian,N., Stafford,G. and Yost,R.A. Imaging of small molecules in tissue sections with a new intermediate-pressure MALDI linear ion trap mass spectrometer. Int. J. Mass Spectrom., 260, 166-176 (2007).
• Gidden,J., Liyanage,R., Durham,B. and Lay,J.O. Reducing fragmentation observed in the matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of triacylglycerols in vegetable oils. Rapid Commun. Mass Spectrom., 21, 1951-1957 (2007).
• Gilleron,M., Lindner,B and Puzo,G. MS/MS approach for characterization of the fatty acid distribution on mycobacterial phosphatidyl-myo-inositol mannosides. Anal. Chem., 78, 8543-8548 (2006).
• Gilleron,M., Quesniaux,V.F.J. and Puzo,G. Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guerin and Mycobacterium tuberculosis H37Rv and its implication in toll-like receptor response. J. Biol. Chem., 278, 29880-29889 (2003).
• Guittard,J., Hronowski,X.P.L. and Costello,C.E. Direct matrix-assisted laser desorption/ionization mass spectrometric analysis of glycosphingolipids on thin-layer chromatographic plates and transfer membranes. Rapid Commun. Mass Spectrom., 13, 1838-1849 (1999).
• Gutierrez,A.L.S., Farage,L., Melo,M.N., Mohana-Borges,R.S., Guerardel,Y., Coddeville,B., Wieruszeski,J.-M., Mendonca-Previato,L. and Previato,J.O. Characterization of glycoinositolphosphoryl ceramide structure mutant strains of Cryptococcus neoformans. Glycobiology, 17, 1C-11C (2007).
• Guyon,F., Absalon,C., Eloy,A., Salagoity,M.H., Esclapez,M. and Medina,B. Comparative study of matrix-assisted laser desorption/ionization and gas chromatography for quantitative determination of cocoa butter and cocoa butter equivalent triacylglycerol composition. Rapid Commun. Mass Spectrom., 17, 2317-2322 (2003).
• Ham,B.M., Jacob,J.T. and Cole,R.B. MALDI-TOF MS of phosphorylated lipids in biological fluids using immobilized metal affinity chromatography and a solid ionic crystal matrix. Anal. Chem., 77, 4439-4447 (2005).
• Ham,B.M., Cole,R.B. and Jacob,J.T. Identification and comparison of the polar phospholipids in normal and dry eye rabbit tears by MALDI-TOF mass spectrometry. Invest. Ophthalmol. Vis. Sci., 47, 3330-3338 (2006).
• Hankin,J.A. and Murphy,R.C. MALDI-TOF and electrospray tandem mass spectrometric analysis of fatty acyl-CoA esters. Int. J. Mass Spectrom. Ion Processes, 165, 467-474 (1997).
• Hartmann,S., Minnikin,D.E., Mallet,A.I., Ridell,M., Rigouts,L. and Portaels,F., Fast atom bombardment mass spectrometry of mycobacterial phenolic glycolipids. Biol. Mass Spectrom., 23, 362-368 (1994).
• Harvey,D.J. Matrix-assisted laser desorption/ionization mass spectrometry of carbohydrates and glycoconjugates. Int. J. Mass Spectrom., 226, 1-35 (2003).
• Harvey,D.J. Matrix-assisted laser desorption/ionization mass spectrometry of phospholipids. J. Mass Spectrom., 30, 1333-1346 (1995).
• Harvey,D.J. Matrix-assisted laser-desorption ionization mass spectrometry of oligosaccharides and glycoconjugates. J. Chromatogr. A, 720, 429-446 (1996).
• Harvey,D.J. Matrix-assisted laser desorption/ionization mass spectrometry of sphingo- and glycosphingolipids. J. Mass Spectrom., 30, 1311-1324 (1995).
• Hidaka,H., Hanyu,N., Sugano,M., Kawasaki,K., Yamauchi,K. and Katsuyama,T. Analysis of human serum lipoprotein lipid composition using MALDI-TOF mass spectrometry. Ann. Clin. Lab. Sci., 37, 213-221 (2007).
• Hlongwane,C., Delves,I.G., Wan,L.W. andAyorinde,F.O. Comparative quantitative fatty acid analysis of triacylglycerols using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and gas chromatography. Rapid Commun. Mass Spectrom., 15, 2027-2034 (2001).
• Hoffman,M.D. and Kast,J. Mass spectrometric characterization of lipid-modified peptides for the analysis of acylated proteins. J. Mass Spectrom., 41, 229-241 (2006).
• Horiuchi,H., Saito,N., Kobayashi,S., Ota,H., Taketomi,T. and Takaoka,K. Avascular necrosis of the femoral head in a patient with Fabry's disease - Identification of ceramide trihexoside in the bone by delayed-extraction matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Arthritis and Rheumatism, 46, 1922-1925 (2002).
• Hossain,H., Wellensiek,H.-J., Geyer,R. and Lochnit,G. Structural analysis of glycolipids from Borrelia burgdorferi. Biochimie, 83, 683-692 (2001).
• Huang,Y., Shen,J., Wang,T., Yu,Y.K., Chen,F.F. and Yang,J. A lipidomic study of the effects of N-methyl-N '-nitro-N-nitrosoguanidine on sphingomyelin metabolism. Acta Bioch. Biophys. Sin., 37, 515-524 (2005).
• Hunnam,V., Harvey,D.J., Priestman,D.A., Bateman,R.H., Bordoli,R.S. and Tyldesley,R. Ionization and fragmentation of neutral and acidic glycosphingolipids with a Q-TOF mass spectrometer fitted with a MALDI ion source. J. Am. Soc. Mass Spectrom., 12, 1220-1225 (2001).
• Iriko,H., Nakamura,K., Kojima,H., Iida-Tanaka,N., Kasama,T., Kawakami,Y., Ishizuka,I., Uchida,A., Murata,Y. and Tamai,Y. Chemical structures and immunolocalization of glycosphingolipids isolated from Diphyllobothrium hottai adult worms and plerocercoids. Eur. J. Biochem., 269, 3549-3559 (2002).
• Ishida,Y., Kitagawa,K., Nakayama,A. and Ohtani,H. On-probe sample pretreatment for direct analysis of lipids in gram-positive bacterial cells by matrix-assisted laser desorption ionization mass spectrometry. Appl. Environm. Microbiol., 71, 7539-7541 (2005).
• Ishida,Y., Madonna,A.J., Rees,J.C., Meetani,M.A. and Voorhees,K.J. Rapid analysis of intact phospholipids from whole bacterial cells by matrix-assisted laser desorption/ionization mass spectrometry combined with on-probe sample pretreatment. Rapid Commun. Mass Spectrom., 16, 1877-1882 (2002).
• Ishida,Y., Nakanishi,O., Hirao,S., Tsuge,S., Urabe,J., Sekino,T., Nakanishi,M., Kimoto,T. and Ohtani,H. Direct analysis of lipids in single zooplankter individuals by matrix-assisted laser desorption/ionization mass spectrometry. Anal. Chem., 75, 4514-4518 (2003).
• Ishida,Y., Kitagawa,K., Nakayama,A. and Ohtani,H. Complementary analysis of lipids in whole bacteria cells by thermally assisted hydrolysis and methylation-GC and MALDI-MS combined with on-probe sample pre-treatment. J. Anal. Appl. Pyrol., 77, 116-120 (2006).
• Ito,M., Matsumuro,Y., Yamada,S., Kitamura,T., Itonori,S. and Sugita,M. Isolation and characterization of a novel uronic acid-containing acidic glycosphingolipid from the ascidian Halocynthia roretzi. J. Lipid Res., 48, 96-103 (2007).
• Itonori,S., Hamana,H., Hada,N., Takeda,T., Dulaney,J.T. and Sugita,M. Structural characterization of a novel series of fucolipids from the marine annelid, Pseudopotamilla occelata. J. Oleo Sci., 50, 537-544 (2001).
• Ivanova,P.T., Milne,S.B., Byrne,M.O., Xiang,Y. and Brown,H.A. Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry. Methods Enzymol., 432, 21-57 (2007).
• Ivleva,V.B., Elkin,Y.N., Budnik,B.A., Moyer,S.C., O'Connor,P.B. and Costello,C.E. Coupling thin-layer chromatography with vibrational cooling matrix-assisted laser desorption/ionization Fourier transform mass spectrometry for the analysis of ganglioside mixtures. Anal. Chem., 76, 6484-6491 (2004).
• Ivleva,V.B., Sapp,L.M., O'Connor,P.B. and Costello,C.E. Ganglioside analysis by thin-layer chromatography matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry. J. Am. Soc. Mass Spectrom., 16, 1552-1560 (2005).
• Jackson,S.N., Wang,H.-Y.J. and Woods,A.S. In situ structural characterization of glycerophospholipids and sulfatides in brain tissue using MALDI-MS/MS. J. Am. Soc. Mass Spectrom., 18, 17-26 (2007).
• Jackson,S.N., Wang,H.Y.J. and Woods,A.S. Direct profiling of lipid distribution in brain tissue using MALDI-TOFMS. Anal. Chem., 77, 4523-4527 (2005).
• Jackson,S.N., Wang,H.Y.J. and Woods,A.S. In situ structural characterization of phosphatidylcholines in brain tissue using MALDI-MS/MS. J. Am. Soc. Mass Spectrom., 16, 2052-2056 (2005).
• Jackson,S.N., Wang,H.Y.J. and Woods,A.S. Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS. J. Am. Soc. Mass Spectrom., 16, 133-138 (2005).
• Jackson,S.N., Ugarov,M., Egan,T., Post,J.D., Langlais,D., Schultz,J.A. and Woods,A.S. MALDI-ion mobility-TOFMS imaging of lipids in rat brain tissue. J. Mass Spectrom., 42, 1093-1098 (2007).
• Jagannadham,M.V. and Nagaraj,R. Detection of peptides covalently modified with multiple fatty acids by MALDI-TOF mass spectrometry. J. Peptide Res., 66, 94-100 (2005).
• Jakab,A., Nagy,K., Heberger,K., Vekey,K. and Forgacs,E. Differentiation of vegetable oils by mass spectrometry combined with statistical analysis. Rapid Commun. Mass Spectrom., 16, 2291-2297 (2002).
• Jeyaretnam,B., Glushka,J., Kolli,V.S.K. and Carlson,R.W. Characterization of a novel lipid-A from Rhizobium species Sin-1. J. Biol. Chem., 277, 41802-41810 (2002).
• Johanson,R.A., Buccafusca,R., Quong,J.N., Shaw,M.A. and Berry,G.T. Phosphatidylcholine removal from brain lipid extracts expands lipid detection and enhances phosphoinositide quantification by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Anal. Biochem., 362, 155-167 (2007).
• Jones,J.J., Batoy,S.M.A.B., Wilkins,C.L., Liyanage,R. and Lay,J.O. Ionic liquid matrix-induced metastable decay of peptides and oligonucleotides and stabilization of phospholipids in MALDI FTMS analyses. J. Am. Soc. Mass Spectrom., 16, 2000-2008 (2005).
• Jones,J.J., Mariccor,S., Batoy,A.B. and Wilkins,C.L. A comprehensive and comparative analysis for MALDI FTMS lipid and phospholipid profiles from biological samples. Comput. Biol. Chem., 29, 294-302 (2005).
• Jones,J.J., Stump,M.J., Fleming,R.C, Lay,J.O. and Wilkins,C.L. Strategies and data analysis techniques for lipid and phospholipid chemistry elucidation by intact cell MALDI-FTMS. J. Am. Soc. Mass Spectrom., 15, 1665-1674 (2004).
• Jones,J.J., Borgmann,S., Wilkins,C.L. and O'Brien,R.M. Characterizing the phospholipid profiles in mammalian tissues by MALDI FTMS. Anal. Chem., 78, 3062-3071 (2006).
• Juhasz,P. and Costello,C.E. Matrix-assisted laser desorption ionization time-of-flight MS of underivatized and permethylated gangliosides. J. Am. Soc. Mass Spectrom., 3, 785-96 (1992).
• Kaltashov,I.A., Doroshenko,V., Cotter,R.J., Takayama,K. and Qureshi,N. Confirmation of the structure of lipid A derived from the lipopolysaccharide of Rhodobacter sphaeroides by a combination of MALDI, LSIMS, and tandem mass spectrometry. Anal. Chem., 69, 2317-2322 (1997).
• Kaufman,M. and Wiesman,Z. Pomegranate oil analysis with emphasis on MALDI-TOF/MS triacylglycerol fingerprinting. J. Agric. Food Chem., 55, 10405-10413 (2007).
• Kaufmann,R., Wingerath,T., Kirsch,D., Stahl,W. and Sies,H. Analysis of carotenoids and carotenol fatty acid esters by matrix-assisted laser desorption ionization (MALDI) and MALDI-post-source-decay mass spectrometry. Anal. Biochem., 238, 117-128 (1996).
• Kawahara,K., Moll,M., Knirel,Y.A, Seydel,U. and Zähringer, U. Structural analysis of two glycosphingolipids from the lipopolysaccharide-lacking bacterium Sphingomonas capsulate. Eur. J. Biochem., 267, 1837-1846 (2000).
• Kawahara,K., Seyde,U., Matsuura,M., Danbara,H., Rietschel,E.T. and Zähringer,U. Chemical structure of glycosphingolipids isolated from Sphingomonas paucimobilis. FEBS Letts, 292, 107-110 (1991).
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Updated: 6/2/2008 Credits/disclaimer	Scottish Crop Research Institute (and MRS Lipid Analysis Unit), Invergowrie, Dundee (DD2 5DA), Scotland